The E3 ligase Itch and deubiquitinase Cyld co-operatively regulate Tak1 and inflammation

Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld form a complex via the interaction through ‘WW-PPXY’ motifs. The Itch-Cyld complex sequentially cleaved K63-linked u...

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Detalles Bibliográficos
Autores principales: Ahmed, Neesar, Zeng, Minghui, Sinha, Indrajit, Polin, Lisa, Wei, Wei-Zen, Rathinam, Chozhavendan, Flavell, Richard, Massoumi, Ramin, Venuprasad, K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219826/
https://www.ncbi.nlm.nih.gov/pubmed/22057290
http://dx.doi.org/10.1038/ni.2157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219826/
https://www.ncbi.nlm.nih.gov/pubmed/22057290
http://dx.doi.org/10.1038/ni.2157

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