Cargando…
The E3 ligase Itch and deubiquitinase Cyld co-operatively regulate Tak1 and inflammation
Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld form a complex via the interaction through ‘WW-PPXY’ motifs. The Itch-Cyld complex sequentially cleaved K63-linked u...
Autores principales: | Ahmed, Neesar, Zeng, Minghui, Sinha, Indrajit, Polin, Lisa, Wei, Wei-Zen, Rathinam, Chozhavendan, Flavell, Richard, Massoumi, Ramin, Venuprasad, K |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219826/ https://www.ncbi.nlm.nih.gov/pubmed/22057290 http://dx.doi.org/10.1038/ni.2157 |
Ejemplares similares
-
CYLD and SUMO in neuroblastoma therapy
por: Masoumi, Katarzyna Chmielarska, et al.
Publicado: (2016) -
Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer
por: Masoumi, K. C., et al.
Publicado: (2011) -
The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
por: Zhang, Lele, et al.
Publicado: (2018) -
UVB radiation represses CYLD expression in melanocytes
por: Kuphal, Silke, et al.
Publicado: (2017) -
Mutual regulation between deubiquitinase CYLD and retroviral oncoprotein Tax
por: Wu, Xuefeng, et al.
Publicado: (2011)