Single Insulin-Specific CD8(+) T Cells Show Characteristic Gene Expression Profiles in Human Type 1 Diabetes

OBJECTIVE: Both the early steps and the high recurrence of autoimmunity once the disease is established are unexplained in human type 1 diabetes. Because CD8(+) T cells are central and insulin is a key autoantigen in the disease process, our objective was to characterize HLA class I–restricted autor...

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Detalles Bibliográficos
Autores principales: Luce, Sandrine, Lemonnier, François, Briand, Jean-Paul, Coste, Joel, Lahlou, Najiba, Muller, Sylviane, Larger, Etienne, Rocha, Benedita, Mallone, Roberto, Boitard, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219929/
https://www.ncbi.nlm.nih.gov/pubmed/21998398
http://dx.doi.org/10.2337/db11-0270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219929/
https://www.ncbi.nlm.nih.gov/pubmed/21998398
http://dx.doi.org/10.2337/db11-0270

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