IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response

OBJECTIVE: Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still unclear. RESEARCH DESIGN AND METHODS: The interplay between IL-21/IL-21R signalin...

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Detalles Bibliográficos
Autores principales: Petrelli, Alessandra, Carvello, Michele, Vergani, Andrea, Lee, Kang Mi, Tezza, Sara, Du, Ming, Kleffel, Sonja, Chengwen, Liu, Mfarrej, Bechara G., Hwu, Patrick, Secchi, Antonio, Leonard, Warren J., Young, Deborah, Sayegh, Mohamed H., Markmann, James F., Zajac, Allan J., Fiorina, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219943/
https://www.ncbi.nlm.nih.gov/pubmed/22013017
http://dx.doi.org/10.2337/db11-0880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219943/
https://www.ncbi.nlm.nih.gov/pubmed/22013017
http://dx.doi.org/10.2337/db11-0880

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