Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion

OBJECTIVE: The glucoincretin hormone glucagon-like peptide 1 (GLP-1) enhances glucose-stimulated insulin secretion and stimulates pancreatic β-cell mass expansion. We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the...

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Detalles Bibliográficos
Autores principales: Bastien-Dionne, Pierre-Olivier, Valenti, Luca, Kon, Ning, Gu, Wei, Buteau, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219950/
https://www.ncbi.nlm.nih.gov/pubmed/22013015
http://dx.doi.org/10.2337/db11-0101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219950/
https://www.ncbi.nlm.nih.gov/pubmed/22013015
http://dx.doi.org/10.2337/db11-0101

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