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Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion

OBJECTIVE: The glucoincretin hormone glucagon-like peptide 1 (GLP-1) enhances glucose-stimulated insulin secretion and stimulates pancreatic β-cell mass expansion. We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the...

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Detalles Bibliográficos
Autores principales:	Bastien-Dionne, Pierre-Olivier, Valenti, Luca, Kon, Ning, Gu, Wei, Buteau, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219950/ https://www.ncbi.nlm.nih.gov/pubmed/22013015 http://dx.doi.org/10.2337/db11-0101

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