Mapping of disease-associated variants in admixed populations

Recent developments in high-throughput genotyping and whole-genome sequencing will enhance the identification of disease loci in admixed populations. We discuss how a more refined estimation of ancestry benefits both admixture mapping and association mapping, making disease loci identification in ad...

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Autores principales: Shriner, Daniel, Adeyemo, Adebowale, Ramos, Edward, Chen, Guanjie, Rotimi, Charles N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219963/
https://www.ncbi.nlm.nih.gov/pubmed/21635713
http://dx.doi.org/10.1186/gb-2011-12-5-223
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author Shriner, Daniel
Adeyemo, Adebowale
Ramos, Edward
Chen, Guanjie
Rotimi, Charles N
author_facet Shriner, Daniel
Adeyemo, Adebowale
Ramos, Edward
Chen, Guanjie
Rotimi, Charles N
author_sort Shriner, Daniel
collection PubMed
description Recent developments in high-throughput genotyping and whole-genome sequencing will enhance the identification of disease loci in admixed populations. We discuss how a more refined estimation of ancestry benefits both admixture mapping and association mapping, making disease loci identification in admixed populations more powerful. High-throughput genotyping and sequencing will enable refined estimation of ancestry, thus enhancing disease loci identification in admixed populations
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spelling pubmed-32199632012-05-30 Mapping of disease-associated variants in admixed populations Shriner, Daniel Adeyemo, Adebowale Ramos, Edward Chen, Guanjie Rotimi, Charles N Genome Biol Review Recent developments in high-throughput genotyping and whole-genome sequencing will enhance the identification of disease loci in admixed populations. We discuss how a more refined estimation of ancestry benefits both admixture mapping and association mapping, making disease loci identification in admixed populations more powerful. High-throughput genotyping and sequencing will enable refined estimation of ancestry, thus enhancing disease loci identification in admixed populations BioMed Central 2011 2011-05-30 /pmc/articles/PMC3219963/ /pubmed/21635713 http://dx.doi.org/10.1186/gb-2011-12-5-223 Text en Copyright ©2011 BioMed Central Ltd.
spellingShingle Review
Shriner, Daniel
Adeyemo, Adebowale
Ramos, Edward
Chen, Guanjie
Rotimi, Charles N
Mapping of disease-associated variants in admixed populations
title Mapping of disease-associated variants in admixed populations
title_full Mapping of disease-associated variants in admixed populations
title_fullStr Mapping of disease-associated variants in admixed populations
title_full_unstemmed Mapping of disease-associated variants in admixed populations
title_short Mapping of disease-associated variants in admixed populations
title_sort mapping of disease-associated variants in admixed populations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219963/
https://www.ncbi.nlm.nih.gov/pubmed/21635713
http://dx.doi.org/10.1186/gb-2011-12-5-223
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