PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction

INTRODUCTION: Lymphocyte apoptosis and monocyte dysfunction play a pivotal role in sepsis-induced immunosuppression. Programmed death-1 (PD1) and its ligand programmed death ligand-1 (PD-L1) exert inhibitory function by regulating the balance among T cell activation, tolerance, and immunopathology....

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yan, Zhou, Ying, Lou, Jingsheng, Li, Jinbao, Bo, Lulong, Zhu, Keming, Wan, Xiaojian, Deng, Xiaoming, Cai, Zailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220038/
https://www.ncbi.nlm.nih.gov/pubmed/21118528
http://dx.doi.org/10.1186/cc9354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220038/
https://www.ncbi.nlm.nih.gov/pubmed/21118528
http://dx.doi.org/10.1186/cc9354

Ejemplares similares