Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination

How do the cullins, with conserved structures, accommodate substrate-binding proteins with distinct shapes and sizes? Cullin-RING E3 ubiquitin ligases facilitate ubiquitin transfer from E2 to the substrate, tagging the substrate for degradation. They contain substrate-binding, adaptor, cullin, and R...

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Detalles Bibliográficos
Autores principales: Liu, Jin, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220518/
https://www.ncbi.nlm.nih.gov/pubmed/21937436
http://dx.doi.org/10.1074/jbc.M111.277236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220518/
https://www.ncbi.nlm.nih.gov/pubmed/21937436
http://dx.doi.org/10.1074/jbc.M111.277236

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