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Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination
How do the cullins, with conserved structures, accommodate substrate-binding proteins with distinct shapes and sizes? Cullin-RING E3 ubiquitin ligases facilitate ubiquitin transfer from E2 to the substrate, tagging the substrate for degradation. They contain substrate-binding, adaptor, cullin, and R...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220518/ https://www.ncbi.nlm.nih.gov/pubmed/21937436 http://dx.doi.org/10.1074/jbc.M111.277236 |