Agents increasing cyclic GMP amplify 5-HT(4)-elicited positive inotropic response in failing rat cardiac ventricle

Activation of 5-HT(4) receptors in failing ventricles elicits a cAMP-dependent positive inotropic response which is mainly limited by the cGMP-inhibitable phosphodiesterase (PDE) 3. However, PDE4 plays an additional role which is demasked by PDE3 inhibition. The objective of this study was to evalua...

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Detalles Bibliográficos
Autores principales: Afzal, Faraz, Qvigstad, Eirik, Aronsen, Jan Magnus, Moltzau, Lise Román, Sjaastad, Ivar, Skomedal, Tor, Osnes, Jan-Bjørn, Levy, Finn Olav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220808/
https://www.ncbi.nlm.nih.gov/pubmed/21901315
http://dx.doi.org/10.1007/s00210-011-0670-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220808/
https://www.ncbi.nlm.nih.gov/pubmed/21901315
http://dx.doi.org/10.1007/s00210-011-0670-6

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