Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands

Here we show that keratinocytes in psoriatic lesional skin express increased Toll-like receptor (TLR) 9 that similarly localizes with elevated expression of the cathelicidin antimicrobial peptide LL-37. In culture, normal human keratinocytes exposed to LL-37 increased TLR9 expression. Furthermore, w...

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Detalles Bibliográficos
Autores principales: Morizane, Shin, Yamasaki, Kenshi, Mühleisen, Beda, Kotol, Paul F., Murakami, Masamoto, Aoyama, Yumi, Iwatsuki, Keiji, Hata, Tissa, Gallo, Richard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220926/
https://www.ncbi.nlm.nih.gov/pubmed/21850017
http://dx.doi.org/10.1038/jid.2011.259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220926/
https://www.ncbi.nlm.nih.gov/pubmed/21850017
http://dx.doi.org/10.1038/jid.2011.259

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