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Tobacco-Specific Nitrosamine-Derived O(2)-Alkylthymidines Are Potent Mutagenic Lesions in SOS-Induced Escherichia coli

[Image: see text] To investigate the biological effects of the O(2)-alkylthymidines induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), we have replicated a plasmid containing O(2)-methylthymidine (O(2)-Me-dT) or O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidin...

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Detalles Bibliográficos
Autores principales: Jasti, Vijay P., Spratt, Thomas E., Basu, Ashis K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221470/
https://www.ncbi.nlm.nih.gov/pubmed/22029400
http://dx.doi.org/10.1021/tx200435d