A Sensitive and Simple HPLC-UV Method for Trace Level Quantification of Ethyl p-Toluenesulfonate and Methyl p-Toluenesulfonate, Two Potential Genotoxins in Active Pharmaceutical Ingredients

A sensitive and simple HPLC/UV method has been developed and validated for the determination of two potential genotoxic impurities, namely methyl p-toluenesulfonate (MPTS) and ethyl p-toluenesulfonate (EPTS) at trace levels in Pemetrexed sodium API. Applying the concept of threshold of toxicological...

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Detalles Bibliográficos
Autores principales: Nageswari, Amasa, Reddy, Kallam Venkata Siva Rama Krishna, Mukkanti, Khagga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221504/
https://www.ncbi.nlm.nih.gov/pubmed/22145110
http://dx.doi.org/10.3797/scipharm.1106-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221504/
https://www.ncbi.nlm.nih.gov/pubmed/22145110
http://dx.doi.org/10.3797/scipharm.1106-23

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