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Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
A functional genetic screen using loss-of-function and gain-of-function alleles was performed to identify modifiers of tau-induced neurotoxicity using the 2N/4R (full-length) isoform of wild-type human tau expressed in the fly retina. We previously reported eye pigment mutations, which create dysfun...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221533/ https://www.ncbi.nlm.nih.gov/pubmed/21949350 http://dx.doi.org/10.1093/hmg/ddr432 |