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Molecular Evolution of the Transmembrane Domains of G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) are a superfamily of integral membrane proteins vital for signaling and are important targets for pharmaceutical intervention in humans. Previously, we identified a group of ten amino acid positions (called key positions), within the seven transmembrane domain (7T...

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Detalles Bibliográficos
Autores principales: Fatakia, Sarosh N., Costanzi, Stefano, Chow, Carson C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221663/
https://www.ncbi.nlm.nih.gov/pubmed/22132149
http://dx.doi.org/10.1371/journal.pone.0027813