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Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats
α-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and bloo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Nutrition Society and the Korean Society of Community Nutrition
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221827/ https://www.ncbi.nlm.nih.gov/pubmed/22125679 http://dx.doi.org/10.4162/nrp.2011.5.5.421 |
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author | Kim, Mi Young Kim, Eun Jin Kim, Young-Nam Choi, Changsun Lee, Bog-Hieu |
author_facet | Kim, Mi Young Kim, Eun Jin Kim, Young-Nam Choi, Changsun Lee, Bog-Hieu |
author_sort | Kim, Mi Young |
collection | PubMed |
description | α-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks. Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC). Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and lipid peroxidation products, malondialdehyde (MDA) concentrations, were analyzed in serum, skin, and liver. Blood lipid profiles were measured, including triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). Skin and liver SOD activities of the ALA and LC groups were higher than those of the CON group (P < 0.05), but serum SOD activity was higher only in the LC group compared to that in the CON group (P < 0.05). Additionally, only liver GSH-Px activity in the LC group was higher than that of the CON and the other groups. Serum and skin MDA levels in the ALA and LC groups were lower than those in the CON group (P < 0.05). Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05). The HDL-C level in the LC group was higher than that in any other group (P < 0.05). LDL-C level was lower in the ALA + LC and LC groups than that in the CON group (P < 0.05). Thus, α-lipoic acid and L-carnosine supplementation increased antioxidant activity, decreased lipid peroxidation in the serum, liver, and skin of rats and positively modified blood lipid profiles. |
format | Online Article Text |
id | pubmed-3221827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Korean Nutrition Society and the Korean Society of Community Nutrition |
record_format | MEDLINE/PubMed |
spelling | pubmed-32218272011-11-28 Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats Kim, Mi Young Kim, Eun Jin Kim, Young-Nam Choi, Changsun Lee, Bog-Hieu Nutr Res Pract Original Research α-Lipoic acid and L-carnosine are powerful antioxidants and are often used as a health supplement and as an ergogenic aid. The objective of this study was to investigate the effects of α-lipoic acid and/or L-carnosine supplementation on antioxidant activity in serum, skin, and liver of rats and blood lipid profiles for 6 weeks. Four treatment groups received diets containing regular rat chow diet (control, CON), 0.5% α-lipoic acid (ALA), 0.25% α-lipoic acid + 0.25% L-carnosine (ALA + LC), or 0.5% L-carnosine (LC). Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and lipid peroxidation products, malondialdehyde (MDA) concentrations, were analyzed in serum, skin, and liver. Blood lipid profiles were measured, including triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C). Skin and liver SOD activities of the ALA and LC groups were higher than those of the CON group (P < 0.05), but serum SOD activity was higher only in the LC group compared to that in the CON group (P < 0.05). Additionally, only liver GSH-Px activity in the LC group was higher than that of the CON and the other groups. Serum and skin MDA levels in the ALA and LC groups were lower than those in the CON group (P < 0.05). Serum TG and TC in the ALA and ALA + LC groups were lower than those in the CON and LC groups (P < 0.05). The HDL-C level in the LC group was higher than that in any other group (P < 0.05). LDL-C level was lower in the ALA + LC and LC groups than that in the CON group (P < 0.05). Thus, α-lipoic acid and L-carnosine supplementation increased antioxidant activity, decreased lipid peroxidation in the serum, liver, and skin of rats and positively modified blood lipid profiles. The Korean Nutrition Society and the Korean Society of Community Nutrition 2011-10 2011-10-28 /pmc/articles/PMC3221827/ /pubmed/22125679 http://dx.doi.org/10.4162/nrp.2011.5.5.421 Text en ©2011 The Korean Nutrition Society and the Korean Society of Community Nutrition http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Kim, Mi Young Kim, Eun Jin Kim, Young-Nam Choi, Changsun Lee, Bog-Hieu Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats |
title | Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats |
title_full | Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats |
title_fullStr | Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats |
title_full_unstemmed | Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats |
title_short | Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats |
title_sort | effects of α-lipoic acid and l-carnosine supplementation on antioxidant activities and lipid profiles in rats |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221827/ https://www.ncbi.nlm.nih.gov/pubmed/22125679 http://dx.doi.org/10.4162/nrp.2011.5.5.421 |
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