Population Pharmacokinetics of Telapristone (CDB-4124) and its Active Monodemethylated Metabolite CDB-4453, with a Mixture Model for Total Clearance

Telapristone is a selective progesterone antagonist that is being developed for the long-term treatment of symptoms associated with endometriosis and uterine fibroids. The population pharmacokinetics of telapristone (CDB-4124) and CDB-4453 was investigated using nonlinear mixed-effects modeling. Dat...

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Detalles Bibliográficos
Autores principales: Morris, Denise, Podolski, Joseph, Kirsch, Alan, Wiehle, Ronald, Fleckenstein, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221841/
https://www.ncbi.nlm.nih.gov/pubmed/22028249
http://dx.doi.org/10.1208/s12248-011-9304-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221841/
https://www.ncbi.nlm.nih.gov/pubmed/22028249
http://dx.doi.org/10.1208/s12248-011-9304-7

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