Cargando…

PEGylating a bacteriophage endolysin inhibits its bactericidal activity

Bacteriophage endolysins (lysins) bind to a cell wall substrate and cleave peptidoglycan, resulting in hypotonic lysis of the phage-infected bacteria. When purified lysins are added externally to Gram-positive bacteria they mediate rapid death by the same mechanism. For this reason, novel therapeuti...

Descripción completa

Detalles Bibliográficos
Autores principales: Resch, Gregory, Moreillon, Philippe, Fischetti, Vincent A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222324/
https://www.ncbi.nlm.nih.gov/pubmed/21982426
http://dx.doi.org/10.1186/2191-0855-1-29