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Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer

We have recently shown that a 150-bp Col10a1 distal promoter (−4296 to −4147 bp) is sufficient to direct hypertrophic chondrocyte-specific reporter (LacZ) expression in vivo. More recently, through detailed sequence analysis we identified two putative tandem-repeat Runx2 binding sites within the 3′-...

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Detalles Bibliográficos
Autores principales: Li, Feifei, Lu, Yaojuan, Ding, Ming, Napierala, Dobrawa, Abbassi, Sam, Chen, Yuqing, Duan, Xiangyun, Wang, Siying, Lee, Brendan, Zheng, Qiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222790/
https://www.ncbi.nlm.nih.gov/pubmed/21887706
http://dx.doi.org/10.1002/jbmr.504