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Asymmetry of (13)C labeled 3-pyruvate affords improved site specific labeling of RNA for NMR spectroscopy

Selective isotopic labeling provides an unparalleled window within which to study the structure and dynamics of RNAs by high resolution NMR spectroscopy. Unlike commonly used carbon sources, the asymmetry of (13)C-labeled pyruvate provides selective labeling in both the ribose and base moieties of n...

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Detalles Bibliográficos
Autores principales: Thakur, Chandar S., Dayie, T. Kwaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222825/
https://www.ncbi.nlm.nih.gov/pubmed/22038649
http://dx.doi.org/10.1007/s10858-011-9581-6