Which Compound to Select in Lead Optimization? Prospectively Validated Proteochemometric Models Guide Preclinical Development

In quite a few diseases, drug resistance due to target variability poses a serious problem in pharmacotherapy. This is certainly true for HIV, and hence, it is often unknown which drug is best to use or to develop against an individual HIV strain. In this work we applied ‘proteochemometric’ modeling...

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Detalles Bibliográficos
Autores principales: van Westen, Gerard J. P., Wegner, Jörg K., Geluykens, Peggy, Kwanten, Leen, Vereycken, Inge, Peeters, Anik, IJzerman, Adriaan P., van Vlijmen, Herman W. T., Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223189/
https://www.ncbi.nlm.nih.gov/pubmed/22132107
http://dx.doi.org/10.1371/journal.pone.0027518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223189/
https://www.ncbi.nlm.nih.gov/pubmed/22132107
http://dx.doi.org/10.1371/journal.pone.0027518

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