A Contracted DNA Repeat in LHX3 Intron 5 Is Associated with Aberrant Splicing and Pituitary Dwarfism in German Shepherd Dogs

Dwarfism in German shepherd dogs is due to combined pituitary hormone deficiency of unknown genetic cause. We localized the recessively inherited defect by a genome wide approach to a region on chromosome 9 with a lod score of 9.8. The region contains LHX3, which codes for a transcription factor ess...

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Detalles Bibliográficos
Autores principales: Voorbij, Annemarie M. W. Y., van Steenbeek, Frank G., Vos-Loohuis, Manon, Martens, Ellen E. C. P., Hanson-Nilsson, Jeanette M., van Oost, Bernard A., Kooistra, Hans S., Leegwater, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223203/
https://www.ncbi.nlm.nih.gov/pubmed/22132174
http://dx.doi.org/10.1371/journal.pone.0027940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223203/
https://www.ncbi.nlm.nih.gov/pubmed/22132174
http://dx.doi.org/10.1371/journal.pone.0027940

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