Efficient discovery of anti-inflammatory small molecule combinations using evolutionary computing

The control of biochemical fluxes is distributed and to perturb complex intracellular networks effectively it is often necessary to modulate several steps simultaneously. However, the number of possible permutations leads to a combinatorial explosion in the number of experiments that would have to b...

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Detalles Bibliográficos
Autores principales: Small, Ben G, McColl, Barry W, Allmendinger, Richard, Pahle, Jürgen, López-Castejón, Gloria, Rothwell, Nancy J, Knowles, Joshua, Mendes, Pedro, Brough, David, Kell, Douglas B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223407/
https://www.ncbi.nlm.nih.gov/pubmed/22020553
http://dx.doi.org/10.1038/nchembio.689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223407/
https://www.ncbi.nlm.nih.gov/pubmed/22020553
http://dx.doi.org/10.1038/nchembio.689

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