Impact of the spotted microarray preprocessing method on fold-change compression and variance stability

BACKGROUND: The standard approach for preprocessing spotted microarray data is to subtract the local background intensity from the spot foreground intensity, to perform a log2 transformation and to normalize the data with a global median or a lowess normalization. Although well motivated, standard a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ambroise, Jérôme, Bearzatto, Bertrand, Robert, Annie, Govaerts, Bernadette, Macq, Benoît, Gala, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224096/
https://www.ncbi.nlm.nih.gov/pubmed/22026942
http://dx.doi.org/10.1186/1471-2105-12-413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224096/
https://www.ncbi.nlm.nih.gov/pubmed/22026942
http://dx.doi.org/10.1186/1471-2105-12-413

Ejemplares similares