Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids

Coumarin-4-acetic acids have been synthesized from various phenols and citric acid under Pechmann cyclisation conditions. All the compounds have been evaluated for antiinflammatory and analgesic activity in acute models. Compounds have also been evaluated for their ulcerogenic potential. Using the c...

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Detalles Bibliográficos
Autores principales: Basanagouda, M., Jadhav, V. B., Kulkarni, M. V., Rao, R. Nagendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2011
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224418/
https://www.ncbi.nlm.nih.gov/pubmed/22131629
http://dx.doi.org/10.4103/0250-474X.89764
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author Basanagouda, M.
Jadhav, V. B.
Kulkarni, M. V.
Rao, R. Nagendra
author_facet Basanagouda, M.
Jadhav, V. B.
Kulkarni, M. V.
Rao, R. Nagendra
author_sort Basanagouda, M.
collection PubMed
description Coumarin-4-acetic acids have been synthesized from various phenols and citric acid under Pechmann cyclisation conditions. All the compounds have been evaluated for antiinflammatory and analgesic activity in acute models. Compounds have also been evaluated for their ulcerogenic potential. Using the computer program, prediction of activity spectra for substances, prediction results and their Pharma Expert software, we have found a correlation between the observed and predicted antiinflammatory activity.
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spelling pubmed-32244182011-11-30 Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids Basanagouda, M. Jadhav, V. B. Kulkarni, M. V. Rao, R. Nagendra Indian J Pharm Sci Short Communications Coumarin-4-acetic acids have been synthesized from various phenols and citric acid under Pechmann cyclisation conditions. All the compounds have been evaluated for antiinflammatory and analgesic activity in acute models. Compounds have also been evaluated for their ulcerogenic potential. Using the computer program, prediction of activity spectra for substances, prediction results and their Pharma Expert software, we have found a correlation between the observed and predicted antiinflammatory activity. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3224418/ /pubmed/22131629 http://dx.doi.org/10.4103/0250-474X.89764 Text en Copyright: © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Basanagouda, M.
Jadhav, V. B.
Kulkarni, M. V.
Rao, R. Nagendra
Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids
title Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids
title_full Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids
title_fullStr Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids
title_full_unstemmed Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids
title_short Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids
title_sort computer aided prediction of biological activity spectra: study of correlation between predicted and observed activities for coumarin-4-acetic acids
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224418/
https://www.ncbi.nlm.nih.gov/pubmed/22131629
http://dx.doi.org/10.4103/0250-474X.89764
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