Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells

BACKGROUND: Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining genetic integrity in cell division. VX-680, a small-molecule Aurora kinase inhibitor, interferes with mitotic entry and formation of bipolar spindles. Here, we evaluated VX-680 as a potential agent for t...

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Detalles Bibliográficos
Autores principales: Xu, Duo-Rong, Huang, Shan, Long, Zi-Jie, Chen, Jia-Jie, Zou, Zheng-Zhi, Li, Juan, Lin, Dong-Jun, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224588/
https://www.ncbi.nlm.nih.gov/pubmed/21600017
http://dx.doi.org/10.1186/1479-5876-9-74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224588/
https://www.ncbi.nlm.nih.gov/pubmed/21600017
http://dx.doi.org/10.1186/1479-5876-9-74

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