Cargando…

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal

BACKGROUND: The integrase (IN) of human immunodeficiency virus type 1 (HIV-1) has been implicated in different steps during viral replication, including nuclear import of the viral pre-integration complex. The exact mechanisms underlying the nuclear import of IN and especially the question of whethe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Levin, Aviad, Armon-Omer, Ayelet, Rosenbluh, Joseph, Melamed-Book, Naomi, Graessmann, Adolf, Waigmann, Elisabeth, Loyter, Abraham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224947/ https://www.ncbi.nlm.nih.gov/pubmed/19961612 http://dx.doi.org/10.1186/1742-4690-6-112

Ejemplares similares

Peptides Derived from HIV-1 Integrase that Bind Rev Stimulate Viral Genome Integration
por: Levin, Aviad, et al.
Publicado: (2009)

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells
por: Levin, Aviad, et al.
Publicado: (2010)

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry
por: Borrenberghs, Doortje, et al.
Publicado: (2016)

Nuclear Localization Signals in Prototype Foamy Viral Integrase for Successive Infection and Replication in Dividing Cells
por: Hossain, Alamgir, et al.
Publicado: (2014)

HIV-1 integrase SUMOylation and viral replication
por: Zamborlini, Alessia, et al.
Publicado: (2011)

Integrase and integration: biochemical activities of HIV-1 integrase
por: Delelis, Olivier, et al.
Publicado: (2008)

Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors
por: Andrake, Mark D, et al.
Publicado: (2008)

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import
por: Demeulemeester, Jonas, et al.
Publicado: (2018)

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import
por: Wagstaff, Kylie M., et al.
Publicado: (2018)

Resistance to Integrase Inhibitors
por: Métifiot, Mathieu, et al.
Publicado: (2010)

Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An in silico analysis
por: Hutapea, Hotma Martogi Lorensi, et al.
Publicado: (2018)

HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses
por: Yan, Zhipeng, et al.
Publicado: (2014)

HIV-2 Integrase Variation in Integrase Inhibitor-Naïve Adults in Senegal, West Africa
por: Gottlieb, Geoffrey S., et al.
Publicado: (2011)

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
por: Koneru, Pratibha C, et al.
Publicado: (2019)

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis
por: Elliott, Jennifer L, et al.
Publicado: (2020)

Prototype Foamy Virus Integrase Displays Unique Biochemical Activities among Retroviral Integrases
por: Rabe, Anthony J., et al.
Publicado: (2021)

New Applications for Phage Integrases
por: Fogg, Paul C.M., et al.
Publicado: (2014)

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases
por: Zhao, Xue Zhi, et al.
Publicado: (2016)

HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants
por: Smith, Steven J., et al.
Publicado: (2021)

The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus
por: McLane, Laura M., et al.
Publicado: (2008)

Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity
por: Woodard, Lauren E., et al.
Publicado: (2009)

A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles
por: Delelis, Olivier, et al.
Publicado: (2005)

Impact of the HIV integrase genetic context on the phenotypic expression and in vivo dynamics of integrase inhibitor resistance mutations
por: Nguyen, Nga, et al.
Publicado: (2013)

Molecular evolution of HIV-1 integrase during the 20 years prior to the first approval of integrase inhibitors
por: Meixenberger, Karolin, et al.
Publicado: (2017)

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
por: Engelman, Alan, et al.
Publicado: (2008)

Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication
por: Larguet, Fadila, et al.
Publicado: (2019)

Multimodal Functionalities of HIV-1 Integrase
por: Engelman, Alan N., et al.
Publicado: (2022)

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import
por: Cribier, Alexandra, et al.
Publicado: (2011)

Identification of low molecular weight nuclear complexes containing integrase during the early stages of HIV-1 infection
por: Gérard, Annabelle, et al.
Publicado: (2013)

Resistance Mutations outside the Integrase Coding Region Have an Effect on Human Immunodeficiency Virus Replicative Fitness but Do Not Affect Its Susceptibility to Integrase Strand Transfer Inhibitors
por: Weber, Jan, et al.
Publicado: (2013)

Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Integrase inhibition
por: Lee-Huang, Sylvia, et al.
Publicado: (2007)

Characterization of natural polymorphic sites of the HIV-1 integrase before the introduction of HIV-1 integrase inhibitors in Germany
por: Meixenberger, Karolin, et al.
Publicado: (2014)

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors
por: Malet, Isabelle, et al.
Publicado: (2017)

Integrase-derived peptides together with CD24-targeted lentiviral particles inhibit the growth of CD24 expressing cancer cells
por: Shapira, Shiran, et al.
Publicado: (2021)

Bracoviruses recruit host integrases for their integration into caterpillar’s genome
por: Wang, Zehua, et al.
Publicado: (2021)

Novel 3′-Processing Integrase Activity Assay by Real-Time PCR for Screening and Identification of HIV-1 Integrase Inhibitors
por: Sakkhachornphop, Supachai, et al.
Publicado: (2015)

Comparison of Newly Assembled Full Length HIV-1 Integrase With Prototype Foamy Virus Integrase: Structure-Function Prospective
por: Dayer, Mohammad Reza
Publicado: (2016)

A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication
por: Serrao, Erik, et al.
Publicado: (2012)

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
por: Desimmie, Belete Ayele, et al.
Publicado: (2013)

Posttranslational Modifications of HIV-1 Integrase by Various Cellular Proteins during Viral Replication
por: Zheng, Yingfeng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_hhlrnijlt2c8f6eou4uaui9eqh