The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

BACKGROUND: Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite substance P(1-7 )(SP(1-7)) and its C-terminal amidated congener induced antihyperalgesic effects in diabetic mice. In this study, we studied a small synthetic dipeptide related...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohsawa, Masahiro, Carlsson, Anna, Asato, Megumi, Koizumi, Takayuki, Nakanishi, Yuki, Fransson, Rebecca, Sandström, Anja, Hallberg, Mathias, Nyberg, Fred, Kamei, Junzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225307/
https://www.ncbi.nlm.nih.gov/pubmed/22040520
http://dx.doi.org/10.1186/1744-8069-7-85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225307/
https://www.ncbi.nlm.nih.gov/pubmed/22040520
http://dx.doi.org/10.1186/1744-8069-7-85

Ejemplares similares