Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia

Exposure of newborn calves to chronic hypoxia causes pulmonary artery (PA) hypertension and remodeling. Previous studies showed that the redox-sensitive transcription factor, early growth response-1 (Egr-1), is upregulated in the PA of chronically hypoxic calves and regulates cell proliferation. Fur...

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Detalles Bibliográficos
Autores principales: Hartney, Tanya, Birari, Rahul, Venkataraman, Sujatha, Villegas, Leah, Martinez, Maylyn, Black, Stephen M., Stenmark, Kurt R., Nozik-Grayck, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225357/
https://www.ncbi.nlm.nih.gov/pubmed/22140445
http://dx.doi.org/10.1371/journal.pone.0027531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225357/
https://www.ncbi.nlm.nih.gov/pubmed/22140445
http://dx.doi.org/10.1371/journal.pone.0027531

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