Structural Basis and Kinetics of Force-Induced Conformational Changes of an αA Domain-Containing Integrin

BACKGROUND: Integrin α(L)β(2) (lymphocyte function-associated antigen, LFA-1) bears force upon binding to its ligand intercellular adhesion molecule 1 (ICAM-1) when a leukocyte adheres to vascular endothelium or an antigen presenting cell (APC) during immune responses. The ligand binding propensity...

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Detalles Bibliográficos
Autores principales: Xiang, Xue, Lee, Cho-yin, Li, Tian, Chen, Wei, Lou, Jizhong, Zhu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225382/
https://www.ncbi.nlm.nih.gov/pubmed/22140490
http://dx.doi.org/10.1371/journal.pone.0027946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225382/
https://www.ncbi.nlm.nih.gov/pubmed/22140490
http://dx.doi.org/10.1371/journal.pone.0027946

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