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Structural Basis and Kinetics of Force-Induced Conformational Changes of an αA Domain-Containing Integrin
BACKGROUND: Integrin α(L)β(2) (lymphocyte function-associated antigen, LFA-1) bears force upon binding to its ligand intercellular adhesion molecule 1 (ICAM-1) when a leukocyte adheres to vascular endothelium or an antigen presenting cell (APC) during immune responses. The ligand binding propensity...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225382/ https://www.ncbi.nlm.nih.gov/pubmed/22140490 http://dx.doi.org/10.1371/journal.pone.0027946 |