Underestimated Effect Sizes in GWAS: Fundamental Limitations of Single SNP Analysis for Dichotomous Phenotypes

Complex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, for some of those traits few significant SNPs have been identified....

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Detalles Bibliográficos
Autores principales: Stringer, Sven, Wray, Naomi R., Kahn, René S., Derks, Eske M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225388/
https://www.ncbi.nlm.nih.gov/pubmed/22140493
http://dx.doi.org/10.1371/journal.pone.0027964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225388/
https://www.ncbi.nlm.nih.gov/pubmed/22140493
http://dx.doi.org/10.1371/journal.pone.0027964

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