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Estimation of synthetic accessibility score of drug-like molecules based on molecular complexity and fragment contributions
BACKGROUND: A method to estimate ease of synthesis (synthetic accessibility) of drug-like molecules is needed in many areas of the drug discovery process. The development and validation of such a method that is able to characterize molecule synthetic accessibility as a score between 1 (easy to make)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225829/ https://www.ncbi.nlm.nih.gov/pubmed/20298526 http://dx.doi.org/10.1186/1758-2946-1-8 |