Cargando…

For debate: substituting placebo controls in long-term Alzheimer's prevention trials

INTRODUCTION: Novel compounds with potential to attenuate or stop the progression of Alzheimer's disease (AD) from its presymptomatic stage to dementia are being tested in man. The study design commonly used is the long-term randomized, placebo-controlled trial (RPCT), meaning that many patient...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spiegel, René, Berres, Manfred, Miserez, André R, Monsch, Andreas U
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226271/ https://www.ncbi.nlm.nih.gov/pubmed/21418632 http://dx.doi.org/10.1186/alzrt68

Ejemplares similares

Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets
por: Berres, Manfred, et al.
Publicado: (2021)

Establishing robust cognitive dimensions for characterization and differentiation of patients with Alzheimer's disease, mild cognitive impairment, frontotemporal dementia and depression
por: Beck, Irene R, et al.
Publicado: (2014)

The 12 Years Preceding Mild Cognitive Impairment Due to Alzheimer’s Disease: The Temporal Emergence of Cognitive Decline
por: Mistridis, Panagiota, et al.
Publicado: (2015)

Cats and Apples: Semantic Fluency Performance for Living Things Identifies Patients with Very Early Alzheimer’s Disease
por: Krumm, Sabine, et al.
Publicado: (2020)

The Montreal Cognitive Assessment: Normative Data from a German-Speaking Cohort and Comparison with International Normative Samples
por: Thomann, Alessandra E., et al.
Publicado: (2018)

The Extension of the German CERAD Neuropsychological Assessment Battery with Tests Assessing Subcortical, Executive and Frontal Functions Improves Accuracy in Dementia Diagnosis
por: Schmid, Nicole S., et al.
Publicado: (2014)

Enhanced diagnostic accuracy for neurocognitive disorders: a revised cut-off approach for the Montreal Cognitive Assessment
por: Thomann, Alessandra E., et al.
Publicado: (2020)

Considering the base rates of low performance in cognitively healthy older adults improves the accuracy to identify neurocognitive impairment with the Consortium to Establish a Registry for Alzheimer’s Disease-Neuropsychological Assessment Battery (CERAD-NAB)
por: Mistridis, Panagiota, et al.
Publicado: (2015)

The Debate over Placebo-Controlled Trials
por: Miller, Frankllin
Publicado: (2005)

Association between changes in cerebral grey matter volume and postoperative cognitive dysfunction in elderly patients: study protocol for a prospective observational cohort study
por: Goettel, Nicolai, et al.
Publicado: (2016)

BrainCheck – a very brief tool to detect incipient cognitive decline: optimized case-finding combining patient- and informant-based data
por: Ehrensperger, Michael M, et al.
Publicado: (2014)

Microstate connectivity alterations in patients with early Alzheimer’s disease
por: Hatz, Florian, et al.
Publicado: (2015)

Ginkgo biloba special extract LI 1370 improves dual-task walking in patients with MCI: a randomised, double-blind, placebo-controlled exploratory study
por: Gschwind, Yves J., et al.
Publicado: (2017)

Probiotics in Medicine: A Long Debate
por: Stavropoulou, Elisavet, et al.
Publicado: (2020)

Distinct neural systems underlying reduced emotional enhancement for positive and negative stimuli in early Alzheimer's disease
por: Mistridis, Panagiota, et al.
Publicado: (2014)

Still debating a cause and diagnostic criteria for Alzheimer's disease
por: Popescu, Bogdan O
Publicado: (2007)

"Minimally Invasive Glaucoma Surgery (MIGS) Is a Poor Substitute for Trabeculectomy"—The Great Debate
por: Bloom, Philip, et al.
Publicado: (2018)

The rose and the name: the unresolved debate on biotechnological terms
por: Domínguez, Martí, et al.
Publicado: (2019)

Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease
por: Gelmont, David, et al.
Publicado: (2016)

Long-term Care Financing: Inserting Politics and Resource Allocation in the Debate: Comment on "Financing Long-term Care: Lessons From Japan"
por: Gori, Cristiano
Publicado: (2019)

Modeling the course of Alzheimer's disease to improve clinical trials: symposium report
por: Spiegel, René, et al.
Publicado: (2013)

Blood‐based biomarkers in Alzheimer's disease: Future directions for implementation
por: Suridjan, Ivonne, et al.
Publicado: (2023)

Debates
por: Pereda, Carlos
Publicado: (1987)

Débat
Publicado: (2004)

Debate
Publicado: (2020)

Caregivers’ acceptance of alternatives to long-term psychiatric hospitalization; lessons and debates from the South Korean situation
por: Lee, Myung-Soo, et al.
Publicado: (2014)

The Use of Sodium Bicarbonate in the Treatment of Acidosis in Sepsis: A Literature Update on a Long Term Debate
por: Velissaris, Dimitrios, et al.
Publicado: (2015)

To debate or not to debate? Examining the contribution of debating when studying medical ethics in small groups
por: Amar-Gavrilman, Nehora, et al.
Publicado: (2022)

OR27-6 Effects of the SGLT2-Inhibitor Empagliflozin in Patients With Chronic Syndrome of Inadequate Antidiuresis (SIAD) - Results of a Double-Blind, Randomized, Placebo-Controlled, Crossover Trial
por: Berres, Manfred, et al.
Publicado: (2022)

Effect of donepezil for dementia prevention in Parkinson's disease with severe hyposmia (The DASH-PD study): A randomized long-term placebo-controlled trial
por: Baba, Toru, et al.
Publicado: (2022)

Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice
por: Skachokova, Zhiva, et al.
Publicado: (2019)

Intelligence and artificial intelligence: an interdisciplinary debate
por: Ratsch, U, et al.
Publicado: (1998)

First do no harm: extending the debate on the provision of preventive tamoxifen
por: Will, B P, et al.
Publicado: (2001)

Football (Soccer) as a Probable Cause of Long-Term Neurological Impairment and Neurodegeneration: A Narrative Review of the Debate
por: Ramsay, Daniele, et al.
Publicado: (2023)

Protocol for a randomised pragmatic policy trial of nicotine products for quitting or long-term substitution in smokers
por: Fraser, Doug, et al.
Publicado: (2015)

Panel debate
por: CERN. Geneva
Publicado: (2018)

Debates constructivistas
Publicado: (1998)

Postmodern debates /
Publicado: (2001)

Debate feminista.
Publicado: (1999)

Fueling the debate.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_ijam1hgk86uqupair2vubn0mpi