Conversion of Tumors into Autologous Vaccines by Intratumoral Injection of α-Gal Glycolipids that Induce Anti-Gal/α-Gal Epitope Interaction

Anti-Gal is the most abundant antibody in humans, constituting 1% of immunoglobulins. Anti-Gal binds specifically α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R). Immunogenicity of autologous tumor associated antigens (TAA) is greatly increased by manipulating tumor cells to express α-gal epitopes and bind...

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Detalles Bibliográficos
Autor principal: Galili, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226304/
https://www.ncbi.nlm.nih.gov/pubmed/22162709
http://dx.doi.org/10.1155/2011/134020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226304/
https://www.ncbi.nlm.nih.gov/pubmed/22162709
http://dx.doi.org/10.1155/2011/134020

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