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The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
Amyloid plaques are defining histopathologic lesions in the brains of Alzheimer's disease (AD) patients and are composed of the amyloid-beta peptide, which is widely considered to play a critical role in the pathogenesis of AD. The β-secretase, or β-site amyloid precursor protein cleaving enzym...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226309/ https://www.ncbi.nlm.nih.gov/pubmed/21639952 http://dx.doi.org/10.1186/alzrt82 |