Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

BACKGROUND: Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through whi...

Descripción completa

Detalles Bibliográficos
Autores principales: Asteriti, Italia A, Giubettini, Maria, Lavia, Patrizia, Guarguaglini, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226445/
https://www.ncbi.nlm.nih.gov/pubmed/22011530
http://dx.doi.org/10.1186/1476-4598-10-131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226445/
https://www.ncbi.nlm.nih.gov/pubmed/22011530
http://dx.doi.org/10.1186/1476-4598-10-131

Ejemplares similares