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Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

BACKGROUND: Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through whi...

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Detalles Bibliográficos
Autores principales:	Asteriti, Italia A, Giubettini, Maria, Lavia, Patrizia, Guarguaglini, Giulia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226445/ https://www.ncbi.nlm.nih.gov/pubmed/22011530 http://dx.doi.org/10.1186/1476-4598-10-131

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