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Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels
The three connexins expressed in the ocular lens each contain PDZ domain–binding motifs directing a physical association with the scaffolding protein ZO-1, but the significance of the interaction is unknown. We found that Cx50 with PDZ-binding motif mutations did not form gap junction plaques or ind...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226470/ https://www.ncbi.nlm.nih.gov/pubmed/21965293 http://dx.doi.org/10.1091/mbc.E11-05-0438 |