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Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels

The three connexins expressed in the ocular lens each contain PDZ domain–binding motifs directing a physical association with the scaffolding protein ZO-1, but the significance of the interaction is unknown. We found that Cx50 with PDZ-binding motif mutations did not form gap junction plaques or ind...

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Detalles Bibliográficos
Autores principales: Chai, Zhifang, Goodenough, Daniel A., Paul, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226470/
https://www.ncbi.nlm.nih.gov/pubmed/21965293
http://dx.doi.org/10.1091/mbc.E11-05-0438