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Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels

The three connexins expressed in the ocular lens each contain PDZ domain–binding motifs directing a physical association with the scaffolding protein ZO-1, but the significance of the interaction is unknown. We found that Cx50 with PDZ-binding motif mutations did not form gap junction plaques or ind...

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Detalles Bibliográficos
Autores principales:	Chai, Zhifang, Goodenough, Daniel A., Paul, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226470/ https://www.ncbi.nlm.nih.gov/pubmed/21965293 http://dx.doi.org/10.1091/mbc.E11-05-0438

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