Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits CD8(+) T cell memory formation

Blimp-1 is a transcriptional repressor that promotes the differentiation of CD8(+) T cells into short-lived KLRG-1(+) effector cells (SLEC), but how it operates remains poorly defined. Here we show that Blimp-1 binds and represses the Id3 promoter in SLEC. Repression of Id3 by Blimp-1 was dispensabl...

Descripción completa

Detalles Bibliográficos
Autores principales: Ji, Yun, Pos, Zoltan, Rao, Mahadev, Klebanoff, Christopher A., Yu, Zhiya, Sukumar, Madhusudhanan, Reger, Robert N., Palmer, Douglas C., Borman, Zachary A., Muranski, Pawel, Wang, Ena, Schrump, David S., Marincola, Francesco M., Restifo, Nicholas P., Gattinoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226770/
https://www.ncbi.nlm.nih.gov/pubmed/22057288
http://dx.doi.org/10.1038/ni.2153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226770/
https://www.ncbi.nlm.nih.gov/pubmed/22057288
http://dx.doi.org/10.1038/ni.2153

Ejemplares similares