hERG1a N-terminal eag domain–containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: A possible mechanism for long QT syndrome

Human ether-á-go-go–related gene (hERG) potassium channels are critical for cardiac action potential repolarization. Cardiac hERG channels comprise two primary isoforms: hERG1a, which has a regulatory N-terminal Per-Arnt-Sim (PAS) domain, and hERG1b, which does not. Isolated, PAS-containing hERG1a N...

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Detalles Bibliográficos
Autores principales: Trudeau, Matthew C., Leung, Lisa M., Roti, Elon Roti, Robertson, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226966/
https://www.ncbi.nlm.nih.gov/pubmed/22124116
http://dx.doi.org/10.1085/jgp.201110683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226966/
https://www.ncbi.nlm.nih.gov/pubmed/22124116
http://dx.doi.org/10.1085/jgp.201110683

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