Cargando…

Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal

Titin exhibits an interaction between its PEVK segment and the actin filament resulting in viscosity, a speed dependent resistive force, which significantly influences diastolic filling in mice. While diastolic disease is clinically pervasive, humans express a more compliant titin (N2BA:N2B ratio ~0...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chung, Charles S., Bogomolovas, Julius, Gasch, Alexander, Hidalgo, Carlos G., Labeit, Siegfried, Granzier, Henk L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227466/ https://www.ncbi.nlm.nih.gov/pubmed/22162634 http://dx.doi.org/10.1155/2011/310791

Ejemplares similares

Titin-Isoform Dependence of Titin-Actin Interaction and Its Regulation by S100A1/Ca(2+) in Skinned Myocardium
por: Fukushima, Hideto, et al.
Publicado: (2010)

Deleting Titin’s C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle
por: van der Pijl, Robbert J., et al.
Publicado: (2020)

Evolution of the Highly Repetitive PEVK Region of Titin Across Mammals
por: Muenzen, Kathleen, et al.
Publicado: (2019)

Removal of immunoglobulin-like domains from titin’s spring segment alters titin splicing in mouse skeletal muscle and causes myopathy
por: Buck, Danielle, et al.
Publicado: (2014)

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line
por: Bogomolovas, Julijus, et al.
Publicado: (2014)

The Poly-E motif in Titin's PEVK region undergoes pH dependent conformational changes
por: Sudarshi Premawardhana, Dassanayake Mudiyanselage, et al.
Publicado: (2020)

Titin‐based mechanosensing modulates muscle hypertrophy
por: van der Pijl, Robbert, et al.
Publicado: (2018)

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere
por: Bogomolovas, Julius, et al.
Publicado: (2021)

Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I
por: Bogomolovas, Julius, et al.
Publicado: (2016)

The giant protein titin regulates the length of the striated muscle thick filament
por: Tonino, Paola, et al.
Publicado: (2017)

Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments
por: Trombitás, Karoly, et al.
Publicado: (1998)

Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis
por: Stergiou, Christos, et al.
Publicado: (2023)

Studies on cardiac myofibrillogenesis with antibodies to titin, actin, tropomyosin, and myosin
Publicado: (1988)

Phosphorylation of Titin Modulates Passive Stiffness of Cardiac Muscle in a Titin Isoform-dependent Manner
por: Fukuda, Norio, et al.
Publicado: (2005)

Some perspectives on the viscosity of actin filaments
Publicado: (1982)

The NH(2) Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity
por: Gregorio, Carol C., et al.
Publicado: (1998)

Contributions of Titin and Collagen to Passive Stress in Muscles from mdm Mice with a Small Deletion in Titin’s Molecular Spring
por: Hettige, Pabodha, et al.
Publicado: (2022)

Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways
por: Rudolf, Rüdiger, et al.
Publicado: (2012)

Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion
por: González-Morales, Nicanor, et al.
Publicado: (2017)

Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells
por: King, Nicholas M.P., et al.
Publicado: (2011)

Calcium increases titin N2A binding to F-actin and regulated thin filaments
por: Dutta, Samrat, et al.
Publicado: (2018)

Computational prediction of actin–actin interaction
por: Ünlü, Ayhan
Publicado: (2013)

The Sarcomeric Protein Nebulin: Another Multifunctional Giant in Charge of Muscle Strength Optimization
por: Ottenheijm, Coen A. C., et al.
Publicado: (2012)

Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator
por: van der Pijl, Robbert J., et al.
Publicado: (2021)

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy
por: Brynnel, Ambjorn, et al.
Publicado: (2018)

Gelsolin-actin interaction and actin polymerization in human neutrophils
Publicado: (1990)

Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy
por: Zhou, Qifeng, et al.
Publicado: (2017)

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice
por: Labeit, Siegfried, et al.
Publicado: (2010)

A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies
por: Gigli, Marta, et al.
Publicado: (2016)

A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation
por: Heidlauf, Thomas, et al.
Publicado: (2017)

Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity
por: Mijailovich, Srboljub M., et al.
Publicado: (2019)

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients
por: Higashikuse, Yuta, et al.
Publicado: (2019)

Role of Titin Missense Variants in Dilated Cardiomyopathy
por: Begay, Rene L., et al.
Publicado: (2015)

Structural basis of the filamin A actin-binding domain interaction with F-actin
por: Iwamoto, Daniel V., et al.
Publicado: (2018)

TRPV2 interacts with actin and reorganizes submembranous actin cytoskeleton
por: Yadav, Manoj, et al.
Publicado: (2020)

The Interaction of Vinculin with Actin
por: Golji, Javad, et al.
Publicado: (2013)

Genetic Ablation of Ankrd1 Mitigates Cardiac Damage during Experimental Autoimmune Myocarditis in Mice
por: Rinkūnaitė, Ieva, et al.
Publicado: (2022)

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance
por: Slater, Rebecca E., et al.
Publicado: (2019)

Increased Expression of N2BA Titin Corresponds to More Compliant Myofibrils in Athlete’s Heart
por: Kellermayer, Dalma, et al.
Publicado: (2021)

Titin and diaphragm dysfunction in mechanically ventilated rats
por: van Hees, Hieronymus W. H., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_fd0l2ienkuncg17piqnakf1mt6