FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

BACKGROUND: Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors. In several cancer cell lines, FADS2 encoded Δ6 and Δ8 des...

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Detalles Bibliográficos
Autores principales: Park, Woo Jung, Kothapalli, Kumar S. D., Lawrence, Peter, Brenna, J. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227664/
https://www.ncbi.nlm.nih.gov/pubmed/22140540
http://dx.doi.org/10.1371/journal.pone.0028186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227664/
https://www.ncbi.nlm.nih.gov/pubmed/22140540
http://dx.doi.org/10.1371/journal.pone.0028186

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