Homology modeling of mosquito cytochrome P450 enzymes involved in pyrethroid metabolism: insights into differences in substrate selectivity

BACKGROUND: Cytochrome P450 enzymes (P450s) have been implicated in insecticide resistance. Anopheles minumus mosquito P450 isoforms CYP6AA3 and CYP6P7 are capable of metabolizing pyrethroid insecticides, however CYP6P8 lacks activity against this class of compounds. FINDINGS: Homology models of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Lertkiatmongkol, Panida, Jenwitheesuk, Ekachai, Rongnoparut, Pornpimol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228512/
https://www.ncbi.nlm.nih.gov/pubmed/21892968
http://dx.doi.org/10.1186/1756-0500-4-321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228512/
https://www.ncbi.nlm.nih.gov/pubmed/21892968
http://dx.doi.org/10.1186/1756-0500-4-321

Ejemplares similares