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Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark of PD is neuronal inclusions termed Lewy bodies whose main component is alpha-synuclein protein. The finding of these Lewy bodies in the intestinal enteric nerves led to the hypothe...

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Detalles Bibliográficos
Autores principales: Forsyth, Christopher B., Shannon, Kathleen M., Kordower, Jeffrey H., Voigt, Robin M., Shaikh, Maliha, Jaglin, Jean A., Estes, Jacob D., Dodiya, Hemraj B., Keshavarzian, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228722/
https://www.ncbi.nlm.nih.gov/pubmed/22145021
http://dx.doi.org/10.1371/journal.pone.0028032