Validation of Skeletal Muscle cis-Regulatory Module Predictions Reveals Nucleotide Composition Bias in Functional Enhancers

We performed a genome-wide scan for muscle-specific cis-regulatory modules (CRMs) using three computational prediction programs. Based on the predictions, 339 candidate CRMs were tested in cell culture with NIH3T3 fibroblasts and C2C12 myoblasts for capacity to direct selective reporter gene express...

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Detalles Bibliográficos
Autores principales: Kwon, Andrew T., Chou, Alice Yi, Arenillas, David J., Wasserman, Wyeth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228787/
https://www.ncbi.nlm.nih.gov/pubmed/22144875
http://dx.doi.org/10.1371/journal.pcbi.1002256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228787/
https://www.ncbi.nlm.nih.gov/pubmed/22144875
http://dx.doi.org/10.1371/journal.pcbi.1002256

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