Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice

Following respiratory syncytial virus infection of adult CB6F1 hybrid mice, a predictable CD8+ T cell epitope hierarchy is established with a strongly dominant response to a K(d)-restricted peptide (SYIGSINNI) from the M2 protein. The response to K(d)M2(82-90) is ∼5-fold higher than the response to...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruckwardt, Tracy J., Malloy, Allison M. W., Gostick, Emma, Price, David A., Dash, Pradyot, McClaren, Jennifer L., Thomas, Paul G., Graham, Barney S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228797/
https://www.ncbi.nlm.nih.gov/pubmed/22144888
http://dx.doi.org/10.1371/journal.ppat.1002377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228797/
https://www.ncbi.nlm.nih.gov/pubmed/22144888
http://dx.doi.org/10.1371/journal.ppat.1002377

Ejemplares similares